C-H Activation in Organic Synthesis (CHAOS)

Welcome to official Website for COST Action CA15106

2nd CHAOS Summer School: Athens, Greece.

10-13 September 2019

Apply for Training School

Deadline: 30.05.2019

Mission Statement

The main aim of this action is to render C-H activation a truly versatile, practical and general tool for organic chemistry, applicable in both industry & academia.
In principal, organic chemists have the tools in hand to prepare any thermodynamically stable molecule by one way or the other. However, even though great achievements have been made in the past century, most of the bond forming reactions rely on preactivated substrates. Additionally, in complex synthesis, protecting group techniques are often required either to block alternative sites of reactivity, or to protect functional groups labile under reaction conditions required for a specific step of a sequence.
The paradigm in organic synthesis has shifted from “getting the job done (the molecule synthesized)” towards getting the job done in the most efficient way possible. The method of metal catalysed C-H activation of organic small molecules has great potential in this regard. At the moment, the field has included many examples of transformations which can be carried out only on specific types of substrates and only few contributions deal with the application of C-H activation in the synthesis of complex molecules such as natural products. Additionally, applications of C-H activation in industrial processes are scarce. Hence, broad applicability, similar to the well establish cross-coupling reactions, has to be established. The time is ripe now to make a big collaborative effort in the area of C-H activation.


The main aim of this Action is to render C-H activation a truly versatile, practical and general tool for organic chemistry, applicable in both industry and academia.

Working Groups

Join any of four Working Groups suitable to your profile, skills and needs. You are welcome to participate in more than one Working Groups.


Perspective of future collaborations and collaborative projects. All members are encouraged to collaborate and excel in the field of CH Activation


Apply for Short-Term Scientific Missions (STSMs) to get experience and skills by visiting participating COST countries for up to 3 months. Keep an eye on open calls!


Attend COST funded meetings in order to share the experience and ideas with CHAOS members

Training Schools

Students from participating COST countries can attend annual Training Schools to get training in relevant fields