CH-Activation in flow

Please find below latest papers on CH activation in flow by Dr. Tomothy Noel

A Modular Flow Design for the meta-Selective C−H Arylation of Anilines

Abstract

Described herein is an effective and practical modular flow design for the meta-selective C−H arylation of anilines. The design consists of four continuous-flow modules (i.e., diaryliodonium salt synthesis, meta-selective C−H arylation, inline copper extraction, and aniline deprotection) which can be operated either individually or consecutively to provide direct access to meta-arylated anilines. With a total residence time of 1 hour, the desired product could be obtained in high yield and excellent purity without the need for column chromatography, and the residual copper content meets the standards for parenterally administered pharmaceutical substances.

External Link

http://onlinelibrary.wiley.com/doi/10.1002/anie.201703369/full

Merger of Visible-Light Photoredox Catalysis and C–H Activation for the Room-Temperature C-2 Acylation of Indoles in Batch and Flow

Abstract

Abstract Image

A mild and versatile protocol for the C–H acylation of indoles via dual photoredox/transition-metal catalysis was established in batch and flow. The C–H bond functionalization occurred selectively at the C-2 position of N-pyrimidylindoles. This room-temperature protocol tolerated a wide range of functional groups and allowed for the synthesis of a diverse set of acylated indoles. Various aromatic as well as aliphatic aldehydes (both primary and secondary) reacted successfully. Interestingly, significant acceleration (20 to 2 h) and higher yields were obtained under micro flow conditions.

External Link

http://pubs.acs.org/doi/abs/10.1021/acscatal.7b00840

0 replies and comments

Leave a Reply

Want to join the discussion?
Feel free to contribute! Your comments are valuable for the CHAOS comminuty!

Leave a Reply

Your email address will not be published. Required fields are marked *