Main Topics and Trainers

Main Topics for the Training School are as follows,

  • Green Chemistry and metal Read sustainability (Prof. Nicholas Gathergood and Dr. Bojan Bondzic)
  • Flow chemistry (Prof. Timothy Noël)
  • Asymmetric synthesis and chirality (Prof. Joanna Wencel-Delord)
  • Advanced NMR course (Dr. Konstantin Luzyanin)
  • Computational chemistry (Prof. Stuart Macgregor)

Practical Workshops and Seminars

  • Flow Chemistry
  • NMR training (by Dr. Ivo Heinmaa, Dr. Jasper Adamson, and  Dr. Ivo Heinmaa)
  • Chiroptical methods for determination of absolute configuration (by Dr. Mohammed Hasan)
  • Application of green metrics for evaluation of reaction efficiency
  • Toxicity and biodegradability tests (by Dr. Villem Aruoja and Dr. Mariliis Sihtmäe)

Flow Chemistry

Flow Chemistry (by Prof. Timothy Noel)

NMR Training

NMR Training  (by Dr. Ivo Heinmaa, Dr. Jasper Adamson, and  Dr. Ivo Heinmaa)

Chiroptical methods for determination of absolute configuration

Chiroptical methods for determination of absolute configuration (by Dr. Mohammed Hasan)

Application of green metrics for evaluation of reaction efficiency Toxicity

Application of green metrics for evaluation of reaction efficiency toxicity (by Dr. Villem Aruoja and Dr. Mariliis Sihtmäe)

Prof. Timothy Noël  obtained his M.Sc. (Industrial Chemical Engineering) in 2004. In 2009, he received his Ph.D. at the University of Ghent. He then moved to the Massachusetts Institute of Technology as a Fulbright Postdoctoral Fellow with Professor Stephen L. Buchwald (MIT-Novartis Center for Continuous Manufacturing). In 2012, he accepted a position as an assistant professor at Eindhoven University of Technology. In 2011, he received an Incentive Award for Young Researchers. In 2012, he received a Veni grant (NWO) and was nominated for the European Young Chemist Award. Since 2014, he has been serving as an associate editor of the Journal of Flow Chemistry. Recently, he received a prestigious VIDI grant (NWO) and he coordinates the Marie Skłodowska-Curie ETN program “Photo4Future”.

Prof. Stuart Macgregor‘s research uses computational chemistry to model chemical structure and reactivity of transition metal systems, especially those of relevance to homogeneous catalysis and metal-mediated organic synthesis. We use techniques based on high-level quantum mechanics, primarily density functional theory and hybrid QM/MM approaches. Most of our work is performed in close collaboration with experimentalists. Stuart did his BSc (1988) and PhD (1992) at the University of Edinburgh, working with Prof. Lesley Yellowlees and Prof.Alan Welch on the structural and electrochemical properties of metallaboranes. He was awarded a NATO Western European Fellowship to work with Prof. Odile Eisenstein at the Université de Paris-Sud in Orsay, near Paris (1992-1994), where he first encountered density functional theory. He then spent two years at the Australian National University in Canberra (1995-1997) before returning to Edinburgh to take up a Lectureship at Heriot-Watt University in 1997. He was promoted to Reader in 2006 and full Professor in 2009 and is currently Head of the Institute of Chemical Sciences within the School of Engineering and Physical Sciences.

Dr. Joanna Wencel-Delord was born in Poland. In 2002, she moved to France to integrate ChemISt (Chemistry International Study) foundation courses at the Ecole Nationale Supérieure de Chimie de Rennes (ENSCR, France). In 2007, she obtained an Engineering Degree from the ENSCR and a research master degree from the University of Rennes 1, France. In 2010, she received her PhD under the supervision of Dr. Christophe Crévisy and Dr. Marc Mauduit (UMR 6226) at the University of Rennes 1. Her PhD work concerned design and evaluation of original chiral ligands for asymmetric transition metal-catalyzed C-C couplings. During a post-doctoral stay in the group of Prof. Frank Glorius at the Westfälische Wilhelms-Universität Münster (Germany), she worked on transition metal-catalyzed C-H activation and she developed original rhodium-catalyzed dehydrogenative arylation and halogenation reactions. In 2012 she joined the group of Prof. Philippe Compain as a temporary assistant professor (ATER) at the University of Strasbourg. Since 2013, she is an associate researcher at CNRS (Centre Nationale de la Recherche Scientifique) in the group of Prof. Françoise Colobert (SynCat, UMR 7509, University of Strasbourg, France). Her current research concerns transition metal-catalyzed asymmetric C-H activation and in particular, application of the atropo-diastereoselective approach to construct axially chiral biaryls.

Dr. Konstantin Luzyanin was born in 1980 in Saint Petersburg, Russian Federation. He studied Chemistry at Saint Petersburg State University, graduating with distinction in 2002. Konstantin received his Ph.D. in chemistry from Technical University of Lisbon (under joint supervision by Profs. A.J.L. Pombeiro and V.Yu. Kukushkin) in 2007. For his Ph.D. thesis, Konstantin was awarded the “António Xavier Prize 2008” from Bruker for applications of the selected NMR spectroscopy techniques in chemistry, and for published works, the Honorous Mention (in Chemistry) – Junior Researcher Prize by Technical University of Lisbon / Deloitte in 2009 and 2010. After postdoctoral studies in organometallic chemistry with Prof. A.J.L. Pombeiro (Instituto Superior Técnico, Technical University of Lisbon), Konstantin got a position as the Senior Research Associate (Ciência-2008 program) at the Centro de Química Estrutural – a research center at the TU Lisbon. In addition, he served as the Manager of IST-UTL Nuclear Magnetic Resonance Center of the Portuguese NMR Network in 2009–2012. During 2012–2013, Konstantin worked as Analytical Services Manager at the School of Physical Sciences, University of Liverpool, United Kingdom. In 2013, he was invited to join the group of Cluster Catalysis (Saint Petersburg State University) as a Deputy Head and a Leading Scientist. In 2015, Konstantin re-joined University of Liverpool as a Scientific Coordinator of the Analytical Services in Department of Chemistry. Konstantin´s current research interests include synthetic transition metals chemistry, in particular of platinum group elements, and development of new methodologies for sustainable/green catalytic processes. He is a co-author of ca. 65 publications (52 papers in international peer-reviewed journals, 4 book chapters, and 5 patents), and more than 50 papers in conference proceedings. In the course of last years, he co-supervised several research grantees, M.Sc. and Ph.D. students, and delivered several university courses.

Prof. Nicholas Gathergood studied chemistry (BSc) at the University of Bath which included a one year industry placement at BP in Sunbury. He completed his PhD with Professor Richard J. Whitby entitled ‘Chiral cyclopentadienyl lanthanide and transition metal complexes’ at the University of Southampton. Postdoctoral research followed with a two year position at Aarhus University, working in Prof. Karl Anker Jorgensen’s group on asymmetric catalytic reactions. In 2001, he joined Prof. Peter J. Scammells and worked at Deakin University, Geelong and the Victorian College of Pharmacy, Melbourne for three years as a postdoctoral fellow. In Australia he worked as a synthetic medicinal chemist on an industry project for GlaxoSmithKline investigating applications of ionic liquid based technologies. Nicholas became a lecturer in organic chemistry at Dublin City University in 2004 where he supervised 10 PhD students to completion. In 2015, he relocated to Tallinn University of Technology, Estonia as the ERA Chair of Green Chemistry. Currently, he is building a new team of talented young academics to promote a green chemistry philosophy throughout the Faculty, Estonia and internationally. In Dublin, his endeavours led to Irish participation in the creation of the EuCheMS Division of Organic Chemistry and support for the EuCheMS Working Party of Green and Sustainable Chemistry. Between 2007 and 2010 he was Chair of the Society of Chemical Industry, Republic of Ireland section. In 2016 he was elected president of the EuCheMS Division of Green and Sustainable Chemistry. He has published over 50 publications including 8 book chapters. He has also co-edited a book, ‘The Role of Green Chemistry in Biomass Processing and Conversion’ published by Wiley. Editorial commitments include Associate editor for Sustainable Chemistry and Pharmacy and founding editorial board member for Current Opinion on Green and Sustainable Chemistry and Current Green Chemistry. His research interests include the design of safer chemicals, green synthetic methodology development and valorisation of chemicals from biomass.

Dr. Bojan Bondzic was born on October 30th, 1981, Serbia. He started his studies at the Faculty of Chemistry, University of Belgrade in 2000 where he graduated in  july 2005, and obtained diploma in Chemistry. He received Annual award of the Serbian Chemical Society in 2005.

As a summer intern student he spent three months  (Jun-September 2003) at the University of Pittsburgh, USA in the group of professor Peter Wipf.

In july 2005 he started his PhD studies at the Deprtment of Organic Chemistry, Faculty of Chemistry at the University of Dortmund, Germany in the group of professor Peter Eilbracht.  In July 2008, he got his PhD in chemistry (doctoral thesis “”Tandem reaction sequences under hydroformylation conditions: Syntheses of indolesand tetrahydro-ß-carbolines”).

From july 2005 to june 2009 he served his military service in Serbia. From July 2009- February 2011 he was  a postdoctoral fellow at the Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Tokyo, Japan,  as a JSPS Postdoctoral fellow in the  group of  Prof. Dr. Yujiro Hayashi where he worked on the development of novel organocatalyzed processes.

Since May 2011 he is employed at the ICTM institute in Serbia as a Senior researcher where he works on the development of novel organocatalyzed reactions in combination with C-H oxidation chemistry as well as in the field of photoredox catalysis.

From november 2012-april 2013 he spent 6 months as a postdoctoral researcher at the Catalysis Research Laboratory (CaRLa), University of   Heidelberg, Germany with professor Peter Hofmann.

He also spent one year (2014-2015) as a postdoctoral researcher at Max-Planck Insitut für Kohlenforschung, Müllheim an der   Ruhr, Germany in the  group of Prof. Dr. Benjamin List where he worked in the field of ACDC catalysis (asymmetric counter ion directed catalysis).

MAIN RESEARCH INTERESTS / EXPERTISE

Current Research interests focus on the development of new synthetic methods, primarily based on combination of organocatalysis with C-H oxidation chemistry as well as asymmetric photoredox processes. Particular interest lies in the enamine catalysis and manipulation of these intermedies towards more complex structures.

Publication list can  be retrieved at: Scopus: https://www.scopus.com/authid/detail.uri?authorId=25225188200

Dr. Jasper Adamson

Following the completion of a B.A. and M.Sci. degree in Natural Sciences at the University of Cambridge in 2009 under the supervision of Prof. David Spring, Dr. Jasper Adamson completed his DPhil at the University of Oxford in 2014 under the supervision of Prof. Andrew Goodwin with a focus on small molecule structure determination. Subsequently, he joined the National Institute of Chemical Physics and Biophysics (NICPB) in Estonia to work as an NMR Research Fellow and implement a number of projects in solution NMR. As of 2017, he has been awarded a grant from the Estonian Research Council and is setting up his research group in supramolecular chemistry. He utilizes crystallography and NMR techniques in his work and is particularly interested in low temperature NMR spectroscopy of dynamic processes. He holds a number of collaborations with the Tallinn University of Technology with his NMR expertise including determining host-guest interactions and binding strengths via NMR titration experiments and variable temperature measurements to determining kinetic parameters for multiple dynamic exchanges.

Practical Workshops and Seminars

Flow Chemistry: practical training includes using of ThalesNano H-Cube pro flow reactor. Performing hydrogenation and coupling reaction in flow.

NMR training

(by Dr. Ivo Heinmaa, Dr. Jasper Adamson, and  Dr. Ivo Heinmaa)

will be held at the National Instituted of Physics and Biophysics (KBFI).

https://kbfi.ee/chemical-physics/research/nuclear-magnetic-resonance-spectroscopy/1443-2/?lang=en

Besides practical trainings, seminars and lectures will be presented by

Dr. Konstantin Luzyanin (University of Liverpool)

Dr. Ivo Heinmaa (KBFI) – solid state NMR (seminar, 1h)

Dr. Ivo Heinmaa (63) graduated physics department of Tartu University in 1977. He started solid state NMR experiments under supervision of Prof E. Lippmaa in National Institute of Chemical Physics and Biophysics (NICPB). With some break in the years 1990-1995, when he worked as a guest-scientist with Prof. W. Zinn and Dr. H. Lütgemeier at Forschungszentrum Jülich, Germany, Ivo has been a Research Fellow at NICPB until today. He received his PhD in 1999 at Tartu University. His main research areas have been NMR applications in High Tc superconductors, in ionic conductors, in endo-fullerenes, in quantum magnets, in polymers etc. He has developed several NMR probes in NICPB for high- and low-temperature applications, including cryo-MAS probe, which is the very probe to get high resolution NMR spectra down to 10K.

He is a co-author of 88 papers in international peer-reviewed journals and one patent application. At present, he is Senior Researcher at NICPB and Principal Investigator of NMR project funded by Estonian Science Agency.

Dr. Jasper Adamson (KBFI) – variable temperature NMR for kinetic and thermodynamic studies (seminar, 1h)

Dr. Jasper Adamson completed his PhD at the University of Oxford in 2014 under the supervision of Prof. Andrew Goodwin and with a focus on small molecule structure determination. He then joined the National Institute of Chemical Physics and Biophysics in Estonia to work as an NMR Research Fellow and implement a number of projects in solution NMR. He holds his own grant from the Estonian Research Council and is slowly setting up his research group in supramolecular chemistry. He utilizes crystallography and NMR techniques in his work and is particularly interested in low temperature NMR spectroscopy of dynamic processes. He holds a number of collaborations with the Tallinn University of Technology with his NMR expertise including determining host-guest interactions and binding strengths via NMR titration experiments and variable temperature measurements to determining kinetic parameters for multiple dynamic exchanges.

 

Dr. Inderk Reile (KBFI) – application of DOSY techniques (seminar, 1h)

Dr. Indrek Reile holds a PhD in organic chemistry from the Tallinn University of Technology in Estonia (2012, supervisor Prof Margus Lopp). His doctoral studies focused on the development of metalloorganic and organocatalytic asymmetric reactions. During his doctoral studies, he worked for 5 months as a visiting researcher with Prof Paul G. Williard in the Brown University (RI, USA), developing asymmetric lithium amide bases. His industrial experience as a chemist includes an industrial placement in drug discovery with GlaxoSmithKline in England and two projects in custom synthesis and API development (TBD-Biodiscovery in Tartu, Estonia). Since all his previous activities had involved extensive work with solution NMR, Dr. Reile joined the National Institute of Chemical Physics and Biophysics (NICPB) as a solution NMR spectroscopist in late 2012. One of the central themes of the position was diffusion NMR studies of organometallic complexes and host-guest chemistry. He then moved to the Radboud University in Nijmegen (the Netherlands) in 2014, where he worked as a postdoc under the supervision of Dr. Marco Tessari and Prof Floris Rutjes, developing parahydrogen hyperpolarization techniques to boost the sensitivity of solution NMR. He has returned to the NICPB in 2017, where he is studying cancer metabolism by NMR and offering diffusion NMR support to other researchers.

Chiroptical methods for determination of absolute configuration

Short (1 h) seminar and practical demonstration of Jasco J-1500 CD instrument – by Dr. Mohammed Hasan (Tallinn University of Technology)

Application of green metrics for evaluation of reaction efficiency

Seminar (1 h) – by Prof. Gathergood (TUT)

Toxicity tests and biodegradability tests

Seminar (1 h) with demonstration of utilities (KBFI)

Toxicity tests at National Institute of Chemical Physics and Biophysics in the Laboratory of Environmental Toxicology

Laboratory of Environmental Toxicology (head dr Anne Kahru) studies the safety of chemicals, synthetic nano materials and complex environmental samples (soils, sediments, wastewater) by combining molecular techniques, in vitro and ecotoxicological assays, and analytical chemistry. The lab has infrastructure, know-how  and up-to-date equipment to conduct various toxicity assays. Model ecotoxicological test organisms include freshwater algae Pseuodkirchneriella subcapitata and crustaceans Daphnia magna and Thamnocephalus platyurus, protozoa Tetrahymena thermophila, marine bacteria Vibrio fischeri and several environmental bacterial strains. Other biological models include various mammalian cell lines in vitro, yeast (Saccharomyces cerevisiae) and bacterial strains (E. coli, Pseudomonas, Staphylococcus, Bacillus).

 

In the current Training School the introductory lecture will give the participants the necessary information on toxicity, toxicity testing and ecotoxicological assays.  In more detail two assays, algae Pseuodkirchneriella subcapitata growth inhibition test and Vibrio fischeri luminescence inhibition test will be presented and the respective facilities shown. Both these assays are powerful tools for obtaining toxicity data for chemical libraries, to build QSAR models. Lectures and practical trainings will be presented by:

Villem Aruoja, res. sci in NICPB, PhD (2011, Estonian University of Life Sciences) started his research in environmental toxicology in 2002, first on heavy metal pollution in soils followed by environmental toxicity of nanoparticles as well as organic chemicals. He has extensive knowledge in algal culturing and toxicity testing.

The algal 72-h growth inhibition test with P. subcapitata (OECD 201):

Algal growth inhibition test: shaker for incubation (left), vial holder constructed for the spectrophotometer for direct optical density measurement (right).

Mariliis Sihtmäe, res.sci. in NICPB. PhD in Chemical and Materials Technology (2011, Tallinn University of Technology). Since 2007 she has been working in the Laboratory of Environmental Toxicology in NICPB. Her current responsibilities and research are related to the regulatory toxicology and (eco)toxicological hazard assessment of different chemicals (incl. nanoparticles and pesticides) with the special focus on different alternatives (e.g in vitro toxicity testing with bacteria, collection and critical analysis of existing toxicity data from different data sources and databases).

  • Bacteria are the simplest systems for toxicological studies on the whole-cell level, toxicity testing with naturally luminescent gram-negative bacteria Vibrio fischeri (ISO 21338:2010) will be introduced.

Microplate luminometer Orion II (left panel) and the kinetic dose-effect curves of luminescence of Vibrio fischeri exposed during 30 seconds to different concentrations of 2-chloroaniline (right panel). RLU – relative light units; control – 2% NaCl.

Further information:

Toxicity of 58 substituted anilines and phenols to algae Pseudokirchneriella subcapitata and bacteria Vibrio fischeri: Comparison with published data and QSARs

Previous trainings organized at our Lab: