WG1:CC

The objective of WG 1 is to develop novel processes for the construction of C‐C bond(s) via transition metal catalyzed C‐H activation for the versatile functionalization and construction of aromatic and heterocyclic systems.

Tasks

T1. Development of efficient, robust and sustainable transition metal based catalytic systems for the C-H activation of organic molecules.

T2. Development of new activation strategies that allow unique transformations and provide highly regio/stereo‐selective transformations.

T3. Design of novel efficient protocols for mild C-H activation

T4. Application of the developed methods in the synthesis of natural products and molecules with potential biological activity.

T5. Development of asymmetric transformations and mechanistic studies in collaboration with WG3 and WG4

Deliverables

In the frame of the COST action the individual and collaborative research of the members of WG1, and other working groups strongly contributes to the development of novel methodologies for the direct C-H bond functionalization including transition metal catalyzed C-H activation. Exchange of complementary expertise and developed transformations broaden the applicability of novel processes and facilitate the design of catalytic systems for the solution of current problems of the field and challenging transformations. In this regard, development of C‐H activation methodologies with more abundant and cheaper transition metals, design of transformations performed under mild reaction conditions in environmentally benign solvents are also in focus of the research projects. The developed functionalization methods and their application in the synthesis of more complex biologically active molecules and natural products would provide valuable synthetic tools for further academic and pharmaceutical research. The mechanistic studies performed in collaboration with the members of WG4 will provide useful information for understanding the developed transformations, which establish future developments in the field of C-H activation.

WG1: CC Documents

Documents

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Working Group Members

Zoltan NOVÁK

MTA-ELTE “Lendület” Catalysis and
Organic Synthesis Research Group
Eötvös Loránd University
Institute of Chemistry
Pázmány Péter stny. 1/a
H-1117 Budapest, Hungary
novakz@elte.hu zng.elte.hu

Giovanna BOSICA

Chemistry
Faculty of Science
Room 310
Chemistry & Pharmacology Building
University of Malta
Msida
giovanna.bosica@um.edu.mt Website

Igor LARROSA

School of Chemistry
University of Manchester
Chemistry Building
Oxford Road
Manchester M13 9PL
igor.larrosa@manchester.ac.uk Website

Marcela DVORAKOVA

Laboratory of Plant Biotechnologies, Rozvojová 313
165 02 Prague 6
Czech Republic
dvorakova@ueb.cas.cz Website

Maria JOÃO PEIXOTO RIBEIRO QUEIROZ

Departamento de Química
Universidade do Minho
Campus de Gualtar
4710-057 Braga, Portugal
mjrpq@quimica.uminho.pt Website

Lukasz PILARSKI

Uppsala University, Department of Chemistry, Husargatan 3, 752 37 Uppsala lukasz.pilarski@kemi.uu.se Website

Alexandros ZOGRAFOS

Aristotle University of Thessaloniki, Department of Chemistry Thessaloniki, 54124
Greece
alzograf@chem.auth.gr Email

Moisés GULÍAS

Address:
Edificio CIQUS, Universidade de Santiago de Compostela 15782, Santiago de Compostela
(Spain)
moises.gulias@usc.es Email

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Pedro J. PEREZ

Address:
Centro de Investigación en Química Sostenible (CIQSO)
Edificio Robert H Grubbs, Campus de El Carmen
Universidad de Huelva
21007 Huelva
perez@dqcm.uhu.es Email

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Jieping ZHU

Address:
Ecole polytechnique fédérale de Lausanne
Institut des sciences et ingénierie chimiques
EPFL SB ISIC LSPN
BCH 5304 (Bât. BCH)
CH-1015 Lausanne
Switzerland
jieping.zhu@epfl.ch Email

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Georgios C. VOUGIOUKALAKIS

Olivier BAUDOIN

Erik VAN DER EYCKEN

Siegfried R. WALDVOGEL

Bojan BONDZIC